Establishment of PFAS CALUX at the Ecotox Centre

PFAS in the environment pose a problem, and various projects at the Ecotox Centre are addressing this issue. These substances can be detected through chemical analysis as well as through bioassays. The PFAS CALUX, based on a genetically modified human cell line, is a bioassay designed to determine the overall effect of PFAS mixtures and is suitable for screening environmental samples. It detects a wide range of PFAS based on their binding affinity to transport proteins. The specific sensitivity may vary depending on the PFAS structure and chain length. The aim of the project is to establish the PFAS CALUX at the Ecotox Centre and to evaluate whether the bioassay offers added value compared to chemical analyses. The test will then be used in projects involving environmental samples.